Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation
Overall, our study suggests asthma patients carrying the extracellular and TIR domain risk haplotype and have a lung microenvironment that promotes elevated levels of cleaved IL33, particularly where IL33<sub>95-270</sub> and IL33<sub>106-270</sub> may be more amenable to IL33/IL1RL1 targeting.
Authors
- Gerard H. Koppelman (ORCID: https://orcid.org/0000-0001-8567-3252)
- Michael A. Portelli (ORCID: https://orcid.org/0000-0003-0821-4575)
- Martijn C. Nawijn (ORCID: https://orcid.org/0000-0003-3372-6521)
- Eszter Csomor (ORCID: https://orcid.org/0000-0001-8195-2481)
- Dominick Shaw (ORCID: https://orcid.org/0000-0003-4106-8469)
- Jonas Emsley (ORCID: https://orcid.org/0000-0002-8949-8030)
- Christopher Edward Brightling (ORCID: https://orcid.org/0000-0002-9345-4903)
- Ian P. Hall (ORCID: https://orcid.org/0000-0001-9933-3216)
- Ian Sayers (ORCID: https://orcid.org/0000-0001-5601-5410)
- Matthew Edwards (ORCID: https://orcid.org/0000-0001-8437-8120)
- Maria E. Ketelaar (ORCID: https://orcid.org/0000-0003-2896-8358)
- Stewart Bates
- Antoon J. van Oosterhout
- Karen Affleck
Institutions
- University Medical Center Groningen (NL)
- University of Nottingham (GB)
- University of Leicester (GB)
- University of Groningen (NL)
- GlaxoSmithKline (United Kingdom) (GB)
- Age UK (GB)
- Glenfield Hospital (GB)
- National Institute for Health and Care Research (GB)
- Nottingham Biomedical Research Centre (GB)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1111/cea.14562
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- GlaxoSmithKline
- Asthma and Lung UK