Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study
This multicenter study demonstrated a link between probands' current tic severity and siblings' neuropsychiatric symptoms. Our study suggests a familial link between TS and ASD-like symptoms, competencies as well as sex-specific associations with ADHD and ODD symptoms in female siblings. The current study sheds light on a broader family tendency and highlights the need for targeted prevention in this vulnerable population. Our findings, however, call for further studies to better understand the genetic and environmental aggregation of influences between individuals with TS, ADHD, and ODD and their siblings.
Authors
- Renata Rizzo (ORCID: https://orcid.org/0000-0002-3997-1328)
- Kerstin Jessica Plessen (ORCID: https://orcid.org/0000-0001-5233-6145)
- Olga Sidiropoulou
- Setareh Ranjbar (ORCID: https://orcid.org/0000-0002-0238-2976)
- Julie Hagstrøm
- Jennifer Glaus (ORCID: https://orcid.org/0000-0001-8883-9473)
- Andrea Dietrich (ORCID: https://orcid.org/0000-0002-2538-6136)
- Pieter J. Hoekstra
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Mental Health Services (DK)
- Copenhagen University Hospital (DK)
- University of Catania (IT)
- Accare (NL)
- University of Lausanne (CH)
Publication Details
- Journal
- JCPP Advances
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1002/jcv2.12277
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Seventh Framework Programme