Gut microbiota-derived acetate promotes long-term recovery through angiogenesis guided by lymphatic ingrowth in older adults with stroke
(a) Gut microbiota-derived acetate promotes angiogenesis post-stroke and (b) lymphatic ingrowth into the cerebral cortex was observed in post-dMCAO mice. These findings suggest that selectively promoting SCFA-producing bacteria, particularly acetate-producers, could be a promising therapeutic strategy to reduce functional impairments in older stroke subjects.
Authors
- Yuxiao Gao
- Bat-Otgon Myagmar
- Linlin Li (ORCID: https://orcid.org/0000-0003-1041-4533)
- Huan Wang (ORCID: https://orcid.org/0000-0002-4057-1145)
- Zhao Wang (ORCID: https://orcid.org/0000-0001-5135-0367)
- Jingjing Wang (ORCID: https://orcid.org/0000-0001-7385-3694)
- Yujia Yuan
- Cong Zhang (ORCID: https://orcid.org/0000-0002-0307-8757)
- Xiangjian Zhang (ORCID: https://orcid.org/0000-0003-0114-1668)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei University of Chinese Medicine (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3389/fnins.2024.1398913
- Citations
- 9
- Primary Topic
- Music Therapy and Health
- Type
- article
- Field-Weighted Citation Impact
- 5.79
Funders
- National Natural Science Foundation of China