Evaluation of Cerebrospinal Fluid <b>α</b>‐Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome
Our results suggest that α-synuclein seeds can be detected in PSP and CBS using a cerebrospinal fluid α-synuclein SAA, and in PSP this may impact on clinical course.
Authors
- Anjum Misbahuddin
- Jennifer Lamoureux
- Marte Theilmann Jensen (ORCID: https://orcid.org/0000-0002-3727-9477)
- Riona Fumi (ORCID: https://orcid.org/0009-0007-4917-6559)
- Thomas T. Warner (ORCID: https://orcid.org/0000-0001-6195-6995)
- Lesley Wu (ORCID: https://orcid.org/0000-0001-5464-5603)
- Megan Hodgson
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- David Vaughan (ORCID: https://orcid.org/0000-0001-7303-6416)
- Edwin Jabbari (ORCID: https://orcid.org/0000-0001-6844-882X)
- Ruth Obrocki
- Christopher Kobylecki (ORCID: https://orcid.org/0000-0002-7797-0756)
- Zane Jaunmuktane (ORCID: https://orcid.org/0000-0001-7738-8881)
- Kieren Allinson (ORCID: https://orcid.org/0000-0003-3468-2110)
- Alistair Church
- Cornelis Blauwendraat (ORCID: https://orcid.org/0000-0001-9358-8111)
- Danielle Lux
- Huw R. Morris (ORCID: https://orcid.org/0000-0002-5473-3774)
- Olaf Ansorge (ORCID: https://orcid.org/0000-0003-1825-5434)
- Tatiana Georgiades (ORCID: https://orcid.org/0009-0007-6165-2490)
- Boyd Ghosh (ORCID: https://orcid.org/0000-0001-5887-9220)
- Kailash P. Bhatia (ORCID: https://orcid.org/0000-0001-8185-286X)
- P. Nigel Leigh
Institutions
- Brighton and Sussex Medical School (GB)
- National Institutes of Health (US)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Royal Gwent Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- National Institute of Neurological Disorders and Stroke (US)
- Amprion (United States) (US)
- Queen's Hospital (GB)
- National Institute on Aging (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1002/mds.30019
- Citations
- 21
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.75
Funders
- Michael J. Fox Foundation for Parkinson's Research
- CurePSP
- PSP Association
- National Institute for Health and Care Research
- Department of Health and Social Care
- Parkinson's UK
- National Institutes of Health
- Medical Research Council
- NIHR Oxford Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre