Combination of circulating tumor cells and <scp>18F</scp>‐<scp>FDG PET</scp>/<scp>CT</scp> for precision diagnosis in patients with non‐small cell lung cancer
Both FDG PET metabolic parameters and CTCs demonstrated diagnostic value for NSCLC, and combining TLG with mixed CTCs could enhance their diagnostic efficacy. The total CTCs and mixed CTCs showed greater diagnostic value than FDG PET in distinguishing benign lesions from Stage I NSCLC. In NSCLC patients, the epithelial CTCs exhibited a positive correlation with SUV<sub>max</sub> and SUL, while mesenchymal CTCs correlated with MTV, and TLG. Besides, epithelial CTCs showed stronger correlations with SUV<sub>max</sub> and SUL, and total CTCs showed stronger correlations with SUV<sub>max</sub>, SUL, MTV, and TLG in Stage I-II NSCLC. Only mesenchymal CTCs in Stage III-IV NSCLC showed correlations with MTV and TLG. Stage IV NSCLC cases displayed a higher number of mesenchymal CTCs.
Authors
- Jin Wang (ORCID: https://orcid.org/0000-0002-3439-0057)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-1567-6666)
- Yang Yang (ORCID: https://orcid.org/0000-0002-0273-9242)
- Xiaoping Li (ORCID: https://orcid.org/0000-0002-4803-4539)
- Jie Shen (ORCID: https://orcid.org/0000-0002-4992-7304)
- Yang Pan (ORCID: https://orcid.org/0009-0001-4594-3948)
- Momo Sun
- Dongyan Lu
Institutions
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.70216
- Citations
- 6
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.51