Trophoblastic disease of the placental bed in the practice of a gynecologist. Case report

Trophoblastic disease is a rare condition. Obstetrician-gynecologists are usually aware of simple hydatidiform mole, invasive mole, and chorioepithelioma. Practitioners are significantly less aware of diseases associated with tumor transformation of the intermediate trophoblast. Such rare forms of trophoblastic disease are almost impossible to diagnose clinically. The morphological differential diagnosis is also quite challenging. Attention to detail and methodical examination of the specimen using various methods ranging from routine staining methods to immunohistochemistry and molecular and cytogenetic typing make it possible to establish the correct diagnosis and choose an effective therapeutic strategy. The article describes a rare clinical case of successfully morphologically diagnosed placental bed involvement, which was manifested by abnormal uterine bleeding in a 26-year-old patient.