Guillain-Barré Syndrome Secondary to Cytomegalovirus Infection in a Pediatric Kidney Transplant Patient

The association between Guillain-Barré syndrome (GBS) and cytomegalovirus (CMV ) is already well established in the literature, "rst reported in 1967. However, this association is rare in solid organ transplant patients, although the incidence of symptomatic CMV infection is higher in this population. Due to its potential severity, high morbidity and mortality, the possibility of GBS cannot be ruled out in the case of neurological complications in transplant patients. In this report, a case of GBS secondary to CMV is described in an eight-year-old kidney transplant patient in the pediatric age group, an interval with an even greater scarcity of reports on this association. !e patient had negative antibodies (IgG and IgM) for CMV in pre-transplant tests, while the donor had positive IgG antibodies, meaning a higher risk of developing the disease. !e clinical condition began approximately two months after the transplant, with classic symptoms and the evolution of GBS. !e clinical aspects, diagnosis, treatment and evolution of the disease are discussed, in addition to the evidence in the world literature.

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Publication Details

Journal
Brazilian Journal of Transplantation
Published
2024-09-16
DOI
https://doi.org/10.53855/bjt.v27i1.609_eng
Primary Topic
Peripheral Neuropathies and Disorders
Type
article
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article

Guillain-Barré Syndrome Secondary to Cytomegalovirus Infection in a Pediatric Kidney Transplant Patient

D. Lopes, Rodrigo Melo Gallindo, Iracy de Oliveira Araújo, Paula Andréa dos Santos Genesio et al.
Brazilian Journal of Transplantation
Peripheral Neuropathies and Disorders
article

Guillain-Barré Syndrome Secondary to Cytomegalovirus Infection in a Pediatric Kidney Transplant Patient

D. Lopes, Rodrigo Melo Gallindo, Iracy de Oliveira Araújo, Paula Andréa dos Santos Genesio, Cassio Tâmara Ribeiro
article en

Abstract

The association between Guillain-Barré syndrome (GBS) and cytomegalovirus (CMV ) is already well established in the literature, "rst reported in 1967. However, this association is rare in solid organ transplant patients, although the incidence of symptomatic CMV infection is higher in this population. Due to its potential severity, high morbidity and mortality, the possibility of GBS cannot be ruled out in the case of neurological complications in transplant patients. In this report, a case of GBS secondary to CMV is described in an eight-year-old kidney transplant patient in the pediatric age group, an interval with an even greater scarcity of reports on this association. !e patient had negative antibodies (IgG and IgM) for CMV in pre-transplant tests, while the donor had positive IgG antibodies, meaning a higher risk of developing the disease. !e clinical condition began approximately two months after the transplant, with classic symptoms and the evolution of GBS. !e clinical aspects, diagnosis, treatment and evolution of the disease are discussed, in addition to the evidence in the world literature.

Brazilian Journal of TransplantationVol. 27(1)
Instituto de Medicina Integral Professor Fernando Figueira (BR)
Good health and well-being
Openalex Percentile: Top 75%
Peripheral Neuropathies and Disorders
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