Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis
Sch B reduces oxidative stress, inflammation, and apoptosis by modulating key targets such as AKT1, ALB, ACE, and CCL5, while activating the PI3K/AKT pathway, leading to improved renal recovery in RIRI.
Authors
- Jiangwei Man
- Tuanjie Che (ORCID: https://orcid.org/0009-0002-6314-6683)
- Liyun Ding (ORCID: https://orcid.org/0000-0002-1625-6145)
- Changhong Xu
- Huabin Wang
- Li Yang
- Yun Deng
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/dddt.s489458
- Citations
- 4
- Primary Topic
- Plant-derived Lignans Synthesis and Bioactivity
- Type
- article
- Field-Weighted Citation Impact
- 0.94