Effect of AML-exosomes on the cellular and molecular properties of bone marrow mesenchymal stromal cells: Expression of JAK/STAT signaling genes
Because the JAK/STAT signaling pathway has been shown to play a role in the proliferation and survival of leukemic cells, our results suggest that AML exosomes stimulate MSCs to activate this pathway. This activation may impede AML cell apoptosis, potentially leading to chemoresistance and relapse.
Authors
- Mehdi Allahbakhshian Farsani (ORCID: https://orcid.org/0000-0002-3910-0119)
- Laya Khodayi Hajipirloo
- Maryam Nabigol
- Bentolhoda Kuhestani-Dehaghi
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Current Research in Translational Medicine
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1016/j.retram.2024.103474
- Citations
- 3
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.31