Canagliflozin and iron metabolism in the CREDENCE trial
Iron deficiency is highly prevalent in patients with type 2 diabetes and CKD. Canagliflozin increased TIBC and decreased ferritin in patients with type 2 diabetes and CKD, suggesting increased iron utilization, and improved hemoglobin levels and clinical outcomes regardless of iron deficiency.
Authors
- Brendon Lange Neuen (ORCID: https://orcid.org/0000-0001-9276-8380)
- Carol A. Pollock (ORCID: https://orcid.org/0000-0001-7167-6495)
- Michael K. Hansen (ORCID: https://orcid.org/0000-0002-0062-0520)
- Niels Jongs (ORCID: https://orcid.org/0000-0002-0882-3656)
- Akihiko Koshino (ORCID: https://orcid.org/0000-0002-9432-2427)
- Hiddo J.L. Heerspink (ORCID: https://orcid.org/0000-0002-3126-3730)
- Stephan J. L. Bakker (ORCID: https://orcid.org/0000-0003-3356-6791)
- Kenneth W. Mahaffey (ORCID: https://orcid.org/0000-0002-3791-2148)
- Clare Arnott (ORCID: https://orcid.org/0000-0001-9370-9913)
- Bruce Charles Neal (ORCID: https://orcid.org/0000-0002-0490-7465)
- Sunil V. Badve (ORCID: https://orcid.org/0000-0003-2269-312X)
- Takashi Wada (ORCID: https://orcid.org/0000-0002-0123-3645)
- Meg Jardine (ORCID: https://orcid.org/0000-0002-0160-2375)
- Vlado Perkovic
Institutions
- Kanazawa University (JP)
- The University of Sydney (AU)
- University Medical Center Groningen (NL)
- Kanazawa Medical University (JP)
- University of Groningen (NL)
- Royal Prince Alfred Hospital (AU)
- Royal North Shore Hospital (AU)
- Concord Repatriation General Hospital (AU)
- UNSW Sydney (AU)
- Kanazawa University Hospital (JP)
- The George Institute for Global Health (AU)
- St George Hospital (AU)
- Janssen (United States) (US)
- Center for Clinical Research (United States) (US)
- St. George Hospital (IN)
- George Institute for Global Health (CN)
- National Health and Medical Research Council (AU)
- Imperial College London (GB)
- Stanford University (US)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1093/ndt/gfae198
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Janssen Research and Development