Evaluation of a point-of-care multiplex immunochromatographic assay for the diagnosis of typhoid: results from a retrospective diagnostic accuracy study
Currently available diagnostic tests for typhoid have several limitations, including low sensitivity and specificity. Dual Path Platform Typhoid assay is a multiplex rapid test that detects IgA antibodies to lipopolysaccharide and hemolysin E antigen. It is considered to have high sensitivity and specificity, and its results were found to be highly correlated with ELISA results. However, very few studies have been conducted to evaluate this test and limited information about the accuracy of this test is present. Hence, this study evaluated the new typhoid test.
Authors
- Javan Esfandiari
- Richelle C. Charles (ORCID: https://orcid.org/0000-0002-8881-1849)
- Jyotshna Sapkota (ORCID: https://orcid.org/0000-0002-3134-7854)
- Kevin K. A. Tetteh (ORCID: https://orcid.org/0000-0003-2733-0037)
- Dhammika Gunasekera
- Hina Shams
- Jason Randolph Andrews (ORCID: https://orcid.org/0000-0002-5967-251X)
- Sabine Dittrich (ORCID: https://orcid.org/0000-0002-4522-2788)
- Zahida Azizullah (ORCID: https://orcid.org/0009-0009-3698-9774)
- Rumina Hasan (ORCID: https://orcid.org/0000-0002-6707-2231)
Institutions
- Aga Khan University (PK)
- FIND (CH)
- Harvard University (US)
- Nepal Medical College Teaching Hospital (NP)
- Massachusetts General Hospital (US)
- Chembio (United States) (US)
- London School of Hygiene & Tropical Medicine (GB)
- Deggendorf Institute of Technology (DE)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1128/jcm.00428-24
- Citations
- 2
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Department of Foreign Affairs and Trade, Australian Government