Walking by design: how to build artificial molecular motors made of proteins
Abstract To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.
Authors
- Nils Gustafsson
- Nancy R. Forde (ORCID: https://orcid.org/0000-0002-5479-7073)
- Paul M. G. Curmi (ORCID: https://orcid.org/0000-0001-5762-7638)
- Chapin S. Korosec (ORCID: https://orcid.org/0000-0001-5137-2195)
- Birte Höcker (ORCID: https://orcid.org/0000-0002-8250-9462)
- Heiner Linke (ORCID: https://orcid.org/0000-0003-4451-4006)
- Neil O. Robertson (ORCID: https://orcid.org/0000-0002-6129-890X)
- Ralf Eichhorn (ORCID: https://orcid.org/0000-0002-7281-1123)
- Anna Zink
- Olivier M.C Laprévote
- Patrik Felix Felix Nilsson
Institutions
- Stockholm University (SE)
- Simon Fraser University (CA)
- Lund University (SE)
- York University (CA)
- UNSW Sydney (AU)
- University of Bayreuth (DE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Nano Futures
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1088/2399-1984/ad7d7e
- Citations
- 1
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- European Commission
- Vetenskapsrådet
- Natural Sciences and Engineering Research Council of Canada
- Australian Research Council
- Elitenetzwerk Bayern