Is the Transcription Factor NANOG Involved in Placental Aging?
The elevated expression of NANOG and KLF4 in abnormal placental tissues suggests their potential role as markers of enhanced placental aging and dysfunction. These findings underscore the importance of the KLF4-NANOG pathway in the pathology of PE, FGR, and PTB, providing a basis for future research into therapeutic targets for these conditions.
Authors
- Debora Kidron
- Sivan Farladansky‐Gershnabel
- Michal Silber
- Tal Biron‐Shental (ORCID: https://orcid.org/0000-0003-4665-7051)
- Tali Zitman‐Gal (ORCID: https://orcid.org/0000-0001-6232-5079)
- Avivit Weisz
- Michal Kovo
Institutions
- Tel Aviv University (IL)
- Meir Medical Center (IL)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/aji.13927
- Citations
- 2
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.47