Loneliness in the college student population: Prevalence and associations with substance use outcomes

<b>Objectives:</b> We assessed the prevalence of loneliness by gender and gender-specific associations between loneliness and substance use in university students. <b>Participants:</b> Participants were students enrolled in colleges and universities throughout the United States (<i>n</i> = 84,481). <b>Methods:</b> Gender was self-reported and categorized as male, female, and transgender/nonbinary. Descriptive analyses were conducted, and logistic regression was used to measure associations between loneliness and substance use by gender and substance. <b>Results:</b> Loneliness prevalence was 58% in the sample, and loneliness was most prevalent among transgender/nonbinary students (79%). Loneliness was associated with reduced odds of alcohol use and increased odds of benzodiazepine use in all genders, and increased odds of marijuana, stimulant, and opioid misuse in females and males. <b>Conclusions:</b> Loneliness is prevalent in college students, especially in transgender/nonbinary students, and it is associated with increased odds of substance use. College administrators should consider implementing interventions to reduce loneliness in this population.