Extensive immunophenotypic sub-population analysis of StemRegenin1 expanded haematopoietic stem/progenitor cells
This study revealed that SR1 selects for potentially novel immunophenotypic HSPC subsets post expansion and has a minimal effect on the transcriptome of 7-day expanded HSPCs when compared to vehicle controls. Whether these distinct immunophenotypic sub-populations possess greater engraftment capacity remains to be tested in animal models.
Authors
- Candice Laverne Hendricks (ORCID: https://orcid.org/0000-0002-3817-6605)
- Michael S. Pepper (ORCID: https://orcid.org/0000-0001-6406-2380)
- Melvin Ambele (ORCID: https://orcid.org/0000-0002-6636-2026)
- Juanita Mellet (ORCID: https://orcid.org/0000-0002-0109-9853)
- Voula Stivaktas
- Chrisna Durandt (ORCID: https://orcid.org/0000-0002-5679-4669)
Institutions
- South African Medical Research Council (ZA)
- Education Labour Relations Council (ZA)
- University of Pretoria (ZA)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s13287-024-03895-x
- Citations
- 6
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- South African Medical Research Council
- University of Pretoria
- Bundesamt für Gesundheit
- Medical Research Council