In vivo biomarkers of <scp>GABA</scp>ergic function in epileptic rats treated with the <scp>GAT</scp>‐1 inhibitor <scp>E2730</scp>
This study identified clinically relevant changes in multimodality imaging and functional purported biomarkers of GABAergic activity during E2730 treatment in epileptic and healthy control animals. These biomarkers could be utilized in clinical trials of E2730 and potentially other GABAergic drugs to provide surrogate endpoints, thereby reducing the cost of such trials.
Authors
- Kazuyuki Fukushima
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Brendan P. Major (ORCID: https://orcid.org/0000-0003-0991-5656)
- Idrish Ali (ORCID: https://orcid.org/0000-0002-0971-4654)
- Nigel C. Jones (ORCID: https://orcid.org/0000-0002-1080-8439)
- Mohammad B. Haskali (ORCID: https://orcid.org/0000-0003-3084-2084)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Peravina Thergarajan (ORCID: https://orcid.org/0000-0003-0778-7232)
- Juliana Silva (ORCID: https://orcid.org/0000-0002-2146-4221)
- Richelle Mychasiuk (ORCID: https://orcid.org/0000-0001-5291-5083)
- Lucy E. Vivash (ORCID: https://orcid.org/0000-0002-1182-0907)
- Robert Brkljača (ORCID: https://orcid.org/0000-0001-6190-2276)
- Patrick Kwan (ORCID: https://orcid.org/0000-0001-7310-276X)
- Jocelyn Y. Cheng (ORCID: https://orcid.org/0000-0001-5318-5668)
- Pablo M. Casillas‐Espinosa (ORCID: https://orcid.org/0000-0002-6199-9415)
- David Wright (ORCID: https://orcid.org/0000-0002-7535-8651)
- Sandy R. Shultz (ORCID: https://orcid.org/0000-0002-2525-8775)
- Glenn R. Yamakawa (ORCID: https://orcid.org/0000-0003-3079-6532)
- Bianca Jupp (ORCID: https://orcid.org/0000-0002-9163-9170)
- Emma L. Braine
- Matthew R. Hudson (ORCID: https://orcid.org/0000-0001-5016-735X)
Institutions
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- Vancouver Island University (CA)
- Alfred Health (AU)
- Eisai (Japan) (JP)
- Monash University (AU)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1111/epi.18119
- Citations
- 5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- U.S. Department of Defense
- Eisai
- Medical Research Council
- National Health and Medical Research Council