Paediatric perioperative hypersensitivity: the performance of the current consensus formula and the effect of uneventful anaesthesia on serum tryptase. Reply to BJA Open 2024; 12: 100307

Editor—It was with great interest that we read the response by Green and colleagues1 to our publication on tryptase in paediatric hypersensitivity.2 We would like to thank the authors for their prompt response to our request for external validation of the new paediatric consensus formula for mast cell activation. Some aspects of their validation study and our original study warrant further discussion. Although the Australian cohort is smaller than the cohort in our previous study (38 vs 190 patients with paired acute and baseline tryptase sampling), it significantly strengthens the validity of our conclusion, both in terms of numerical representation and geographical distribution.