A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity
The respective improvements in β-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity.
Authors
- Sonja M. Reichert (ORCID: https://orcid.org/0000-0003-3914-7010)
- Natalia McInnes (ORCID: https://orcid.org/0000-0003-1495-3825)
- Jiajie Pu (ORCID: https://orcid.org/0009-0008-1229-0734)
- Hertzel C. Gerstein (ORCID: https://orcid.org/0000-0001-8072-2836)
- Caroline K. Kramer (ORCID: https://orcid.org/0000-0003-1064-0100)
- Ravi Retnakaran (ORCID: https://orcid.org/0000-0003-1989-027X)
- Alexandra Emery
- Bernard Zinman (ORCID: https://orcid.org/0000-0002-0041-1876)
- Stewart B. Harris (ORCID: https://orcid.org/0000-0002-8282-5449)
- Chang Ye
Institutions
- Western University (CA)
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- McMaster University (CA)
Publication Details
- Journal
- Diabetes Care
- Published
- 2024-09-20
- DOI
- https://doi.org/10.2337/dc24-1375
- Citations
- 13
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.65
Funders
- Canadian Institutes of Health Research