Gegen Qinlian decoction alleviates depression-like behavior by modulating the gut microenvironment in CUMS rats
Our findings provide evidence supporting the therapeutic efficacy of GQD in alleviating depression-like behavior in CUMS rats, potentially being targeted on colon bacteria (especially the abundance of Ruminococcus and Bacteroides) and metabolites (especially the level of Oleanolic acid).
Authors
- Weichao Pan
- Yu Fan (ORCID: https://orcid.org/0000-0001-6813-6797)
- Hee Young Kim (ORCID: https://orcid.org/0000-0002-9471-0542)
- Qinglong Cai (ORCID: https://orcid.org/0000-0001-8514-2574)
- Yaqin Peng (ORCID: https://orcid.org/0000-0003-3094-1701)
- Xiaowei Guan (ORCID: https://orcid.org/0000-0003-1393-6214)
- Dekang Liu (ORCID: https://orcid.org/0000-0001-6550-0741)
- Feifei Ge (ORCID: https://orcid.org/0000-0003-1336-8587)
- Hongxiu Song
- Yuning Mai (ORCID: https://orcid.org/0000-0001-8209-0289)
- Tao Hu (ORCID: https://orcid.org/0000-0001-7893-096X)
- Yao Du
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0001-7426-1092)
- Ze Wang (ORCID: https://orcid.org/0009-0009-7873-0779)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Yonsei University (KR)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12906-024-04638-4
- Citations
- 14
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province