MicroRNA-199a-5p attenuates blood-brain barrier disruption following ischemic stroke by regulating PI3K/Akt signaling pathway
MiR-199a-5p mimic decreased the expression of PIK3R2 and activated Akt signaling pathway after ischemia stroke, reduced the expression of inflammatory cytokines, and attenuated BBB disruption after ischemic stroke.
Authors
- Guangxiao Ni (ORCID: https://orcid.org/0000-0002-9080-5042)
- Pu Wang (ORCID: https://orcid.org/0000-0002-7292-366X)
- Lulu Kou
- Chun-Qiao Duan
- Ran Meng
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1371/journal.pone.0306793
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province