Enantioselective Synthesis of <i>P</i>-Chiral Phosphine Oxides Bearing an All-Carbon Quaternary Stereogenic Center via Palladium-Catalyzed Domino Heck–Suzuki Reaction
An approach has been developed for the enantioselective synthesis of P-chiral phosphine oxides bearing an all-carbon quaternary stereogenic center via a Pd-catalyzed domino Heck–Suzuki reaction. The origin of the mechanistic preference leading to high diastereo- and enantioselectivities under the Pd catalysis based on a TADDOL-derived phosphoramidite ligand was rationalized on the basis of DFT calculations.
Authors
- Terumasa Kato (ORCID: https://orcid.org/0000-0001-6914-9389)
- Siyu Zhao (ORCID: https://orcid.org/0000-0001-6278-3387)
- Keiji Maruoka (ORCID: https://orcid.org/0000-0002-0044-6411)
- Jiahao Liu (ORCID: https://orcid.org/0000-0002-7820-042X)
- Yan Liu (ORCID: https://orcid.org/0000-0002-3864-1992)
- Zhe Wang (ORCID: https://orcid.org/0000-0001-9232-3699)
- Xue‐Mei Chen (ORCID: https://orcid.org/0009-0005-2005-019X)
- Xunfang Xu
Institutions
- Guangdong University of Technology (CN)
- Kyoto University (JP)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1021/acscatal.4c04958
- Citations
- 11
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.74
Funders
- National Natural Science Foundation of China
- Guangdong Provincial Pearl River Talents Program
- Japan Society for the Promotion of Science