New peptide-porphyrin conjugates targeting brainresiding viruses
We have developed successful on-resin synthesis of new PPCs by DIC/oxyma activation strategy as most suitable and effective approach. All conjugates were well characterized with purity > 90 % and most of them were able to successfully pass the BBB. We have identified several PPCs with high antiviral activity (some of them reaching nanomolar range) against ZIKV.
Authors
- Marco Cavaco (ORCID: https://orcid.org/0000-0002-0938-9038)
- Patrizia Janković (ORCID: https://orcid.org/0000-0002-8904-4004)
- Miguel A. R. B. Castanho (ORCID: https://orcid.org/0000-0001-7891-7562)
- Andrea T. Da Poian (ORCID: https://orcid.org/0000-0002-3969-704X)
- Giuseppina Guida (ORCID: https://orcid.org/0009-0005-3804-9613)
- Christine Cruz-Oliveira (ORCID: https://orcid.org/0000-0003-4838-0703)
- Toni Todorovski (ORCID: https://orcid.org/0000-0002-9168-2830)
- Sira Defaus (ORCID: https://orcid.org/0000-0002-3106-458X)
- Daniela Kalafatović (ORCID: https://orcid.org/0000-0002-9685-1162)
- David Andreu (ORCID: https://orcid.org/0000-0002-6317-6666)
- Diogo Mendonça
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1217
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00