Sustained nerve growth factor-induced C-nociceptor sensitization to electrical sinusoidal stimulation in humans
Exceptionally long sensitization of CM and CMi nociceptors by rhNGF, uncovered by suprathreshold electrical sinusoidal stimulation, indicates a signal transduction-independent long-lasting hyperexcitability of C-nociceptors that clinically may contribute to rhNGF-maintained chronic inflammatory pain.
Authors
- Hans Jürgen Solinski (ORCID: https://orcid.org/0000-0001-6606-3731)
- Roman Rukwied (ORCID: https://orcid.org/0000-0003-4118-497X)
- Martin Schmelz (ORCID: https://orcid.org/0000-0002-9736-7241)
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Bernstein Center for Computational Neuroscience Heidelberg-Mannheim (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- PAIN Reports
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1097/pr9.0000000000001190
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft