Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy
We identified a developmental phenotype in individuals with drug-resistant JME characterized by changes in cortical surface area and folding complexity, the extent of which correlates with executive dysfunction. No association was observed between cortical thickness and disease severity. Our findings support a neurodevelopmental basis for drug resistance and cognitive impairment in JME.
Authors
- John S. Duncan (ORCID: https://orcid.org/0000-0002-1373-0681)
- Fenglai Xiao (ORCID: https://orcid.org/0000-0003-1308-6539)
- Lorenzo Caciagli (ORCID: https://orcid.org/0000-0001-7189-9699)
- Lucas Johannes Rainer (ORCID: https://orcid.org/0000-0002-5377-8110)
- Britta Wandschneider (ORCID: https://orcid.org/0000-0001-7181-2637)
- Martin Kronbichler (ORCID: https://orcid.org/0000-0003-2240-2812)
- Matthias J. Koepp (ORCID: https://orcid.org/0000-0002-4277-8000)
- Christian Vollmar (ORCID: https://orcid.org/0000-0002-4630-7484)
- Eugen Trinka (ORCID: https://orcid.org/0000-0002-5950-2692)
- Bernardo Crespo Pimentel (ORCID: https://orcid.org/0000-0002-8965-8081)
- Giorgi Kuchukhidze (ORCID: https://orcid.org/0000-0001-6899-8506)
- Julia Hoefler
Institutions
- Paracelsus Medical University (AT)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1212/wnl.0000000000209802
- Citations
- 8
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.08
Funders
- GlaxoSmithKline
- Sanofi
- Biogen
- Wellcome Trust
- Jazz Pharmaceuticals
- LivaNova
- GW Pharmaceuticals
- European Commission
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- Eisai
- Bundesministerium für Wissenschaft und Forschung
- G.L. Pharma
- Epilepsy Society
- Medical Research Council
- UCB Pharma