Pembrolizumab or Placebo With Chemoradiotherapy Followed by Pembrolizumab or Placebo for Newly Diagnosed, High-Risk, Locally Advanced Cervical Cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): A Randomized, Double-Blind, Phase 3 Clinical Trial
(Abstracted from Lancet 2024;403:1341–1350) Prognosis for locally advanced cervical cancer is poor, with 5-year progression-free survival (PFS) and overall survival ranging from 47% to 80%. For the past several decades, treatment has included external beam radiotherapy with concurrent chemotherapy followed by brachytherapy, and novel therapeutic options are needed.
Authors
- Jalid Sehouli (ORCID: https://orcid.org/0000-0002-5963-6623)
- Vladyslav Sukhin (ORCID: https://orcid.org/0000-0002-4403-3707)
- Rudolf Lampé (ORCID: https://orcid.org/0000-0002-8230-7692)
- Ari Reiss
- Giovanni Scambia (ORCID: https://orcid.org/0000-0002-9503-9041)
- Roberta Lazzari
- Andrea Juliana Gomes (ORCID: https://orcid.org/0000-0001-7388-663X)
- Chih‐Long Chang (ORCID: https://orcid.org/0000-0003-3981-9366)
- Valeriya Saevets
- Stephan Polterauer (ORCID: https://orcid.org/0000-0002-9649-4505)
- Alejandro Acevedo
- Flora Zagouri (ORCID: https://orcid.org/0000-0001-7153-6556)
- Tomoka Usami (ORCID: https://orcid.org/0009-0004-5742-6421)
- Karin Yamada
- Stephen J. O’Keefe (ORCID: https://orcid.org/0000-0003-4422-3145)
- Linda Duska (ORCID: https://orcid.org/0000-0002-8878-4123)
- Ekkasit Tharavichitkul
- Domenica Lorusso (ORCID: https://orcid.org/0000-0003-0981-0598)
- Ali̇ Ayhan (ORCID: https://orcid.org/0000-0001-7155-9096)
- Noelle Cloven
- Ana Oaknin (ORCID: https://orcid.org/0000-0002-3592-7194)
- Kristina Lindemann (ORCID: https://orcid.org/0000-0002-2162-0175)
- Lucy Gilbert (ORCID: https://orcid.org/0000-0001-8605-5472)
- Jung‐Yun Lee (ORCID: https://orcid.org/0000-0001-7948-1350)
- Fernando Contreras Mejía (ORCID: https://orcid.org/0000-0003-1859-5906)
- Sandro Pignata (ORCID: https://orcid.org/0000-0002-8836-2633)
- Hong Zhu (ORCID: https://orcid.org/0000-0002-3659-8070)
- Kosei Hasegawa (ORCID: https://orcid.org/0000-0002-1903-7001)
- Pier Ramos-Elías
- Kan Li (ORCID: https://orcid.org/0000-0002-5762-7440)
- Yang Xiang (ORCID: https://orcid.org/0000-0002-9112-1021)
- Manuel Leiva
- Sarper Toker
- Melissa Christiaens
Publication Details
- Journal
- Obstetrical & Gynecological Survey
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1097/ogx.0000000000001317
- Citations
- 2
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.17