Resource use and costs of investigator-sponsored randomized clinical trials in Switzerland, Germany, and the United Kingdom: a metaresearch study
Over a quarter of total trial costs were incurred in the planning phase, which is typically not fully funded. Two-thirds of RCTs exceeded their budget by more than 50%. Investigators and funders should consider empirical cost data to improve budgeting and funding practices.
Authors
- Matthias Briel (ORCID: https://orcid.org/0000-0002-2070-5230)
- Alain Amstutz (ORCID: https://orcid.org/0000-0003-1716-993X)
- Benjamin Speich (ORCID: https://orcid.org/0000-0002-3301-8085)
- Ala Taji Heravi (ORCID: https://orcid.org/0000-0003-3752-1611)
- L. Hausheer
- Alexandra Griessbach (ORCID: https://orcid.org/0000-0003-3726-1856)
- Matthias Schwenkglenks (ORCID: https://orcid.org/0000-0001-7217-1173)
- Shaun P. Treweek (ORCID: https://orcid.org/0000-0002-7239-7241)
- Stefan Schandelmaier (ORCID: https://orcid.org/0000-0002-8429-0337)
- Manuela Covino
- Hillary Wnfried Ramirez
Institutions
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Department of Biomedicine Basel (CH)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.jclinepi.2024.111536
- Citations
- 5
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 5.65
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung