Feasibility, Safety, and Factors Predicting Completion of CROSS Protocol–Based Neoadjuvant Chemoradiotherapy for Esophageal Squamous Carcinoma: Experience from an Indian Tertiary Care Cancer Center
In this study, ESCC patients receiving the CROSS protocol NACRT could complete their radiotherapy component, but a significant proportion exhibited poor chemotherapy tolerance. Neutropenia was a major factor limiting chemotherapy delivery, but anemia, high CCI, and conventional radiation techniques were also associated with noncompletion of chemotherapy. The omission of a few chemotherapy cycles had no significant effect on the pathological response; however, its impact on cancer survival requires further evaluation.
Authors
- Suraj Surendran (ORCID: https://orcid.org/0000-0003-4836-9432)
- Simon Pavamani (ORCID: https://orcid.org/0000-0001-6258-1574)
- Myla Yacob (ORCID: https://orcid.org/0000-0002-5315-5239)
- Inian Samarasam (ORCID: https://orcid.org/0000-0002-7800-9318)
- Thenmozhi Mani (ORCID: https://orcid.org/0000-0002-3932-5625)
- Sudhakar Chandran (ORCID: https://orcid.org/0000-0002-2658-5049)
- Balu Krishna Sasidharan (ORCID: https://orcid.org/0000-0002-2814-161X)
- Negine Paul (ORCID: https://orcid.org/0000-0003-4397-1985)
- Geet Midha (ORCID: https://orcid.org/0000-0003-1027-0859)
- Rajesh Isiah
- Manu Mathew (ORCID: https://orcid.org/0000-0003-1692-0058)
- Subhashini John
- Vijay Abraham
Institutions
- Christian Medical College, Vellore (IN)
- Christian Medical College (IN)
Publication Details
- Journal
- South Asian Journal of Cancer
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1055/s-0044-1789275
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00