Trigeminal neuralgia, demyelinating polyneuropathy, and central nervous system involvement in a patient with an <i>SH3TC2</i> mutation

Any patient with slowly progressive peripheral nervous system symptoms and disproportionally abnormal nerve conduction study findings should be tested for an inherited polyneuropathy and brain imaging for screening of possible central nervous system involvement should be performed. Further investigation is needed to elucidate the pathogenetic basis of CMT4C and a possible association with white matter lesions.