Enhanced Plaque Stabilization Effects of Alirocumab ― Insights From Artificial Intelligence-Aided Optical Coherence Tomography Analysis of the Alirocumab for Thin-Cap Fibroatheroma in Patients With Coronary Artery Disease Estimated by Optical Coheren
AI-aided OCT analysis objectively showed greater plaque stabilization of adding alirocumab to rosuvastatin. Our results highlight the benefits of a fully automated AI-assisted approach for assessing drug efficacy, offering greater objectivity in evaluating serial changes in plaque stability vs. conventional OCT assessment.
Authors
- Yuto Osumi (ORCID: https://orcid.org/0000-0003-0177-0173)
- Yoichiro Sugizaki (ORCID: https://orcid.org/0009-0005-2092-4360)
- Koshi Matsuhama (ORCID: https://orcid.org/0009-0007-2973-2976)
- Shengxian Tu (ORCID: https://orcid.org/0000-0001-9681-1067)
- Hiroshi Tsunamoto
- Hiromasa Otake (ORCID: https://orcid.org/0000-0001-9953-0551)
- Shota Naniwa (ORCID: https://orcid.org/0009-0004-9062-8869)
- Hiroyuki Kawamori (ORCID: https://orcid.org/0000-0001-6810-447X)
- Yuta Fukuishi
- Tetsuya Yamamoto (ORCID: https://orcid.org/0000-0003-4444-0289)
- Takayoshi Toba (ORCID: https://orcid.org/0000-0002-0205-928X)
- Hiroya Okamoto
- Tomoyo Hamana (ORCID: https://orcid.org/0009-0005-0013-3166)
- Seigo Iwane (ORCID: https://orcid.org/0009-0004-1895-7828)
- Satoru Sasaki (ORCID: https://orcid.org/0000-0002-7899-8099)
- Hiroyuki Fujii (ORCID: https://orcid.org/0009-0004-8946-6970)
- Yuki Sakamoto (ORCID: https://orcid.org/0000-0002-1592-3647)
- Kotaro Higuchi
- Ken–ichi Hirata
- Takashi Hiromasa
Institutions
- Shanghai Jiao Tong University (CN)
- University of Oxford (GB)
- Kobe University (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1253/circj.cj-24-0480
- Citations
- 14
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.02