Peptide stapling - application in antibacterial therapies
Goal of our reaserchAs aminoglycosides, we chose amikacin (AMK) and neomycin (NEO).We proposed two methods for conjugating peptides with AMK and NEO: a non-cleavable triazole ring formed through a 'click chemistry' reaction, and a disulfide bond, which is cleavable in the bacterial cytosol.
Authors
- Julia Macyszyn (ORCID: https://orcid.org/0000-0002-2501-4391)
- Joanna Miszkiewicz (ORCID: https://orcid.org/0000-0002-2490-7833)
- Michał Burmistrz (ORCID: https://orcid.org/0000-0002-2350-0003)
- Monika Wojciechowska (ORCID: https://orcid.org/0000-0002-6255-6421)
- Joanna Trylska (ORCID: https://orcid.org/0000-0002-1464-5323)
- Małgorzata Lobka (ORCID: https://orcid.org/0009-0006-3327-5010)
Institutions
- United Technologies Corporation (Poland) (PL)
Publication Details
- Published
- 2024-09-20
- DOI
- https://doi.org/10.17952/37eps.2024.p1058
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00