Harnessing ZIKV NS2A RNA for alleviating acute hepatitis and cytokine release storm by targeting translation machinery
Zika virus NS2A dampens the production of proinflammatory cytokines and alleviates inflammatory injuries by interfering translation process as RNA molecules, which suggests that NS2A RNA is potentially used to treat numerous acute inflammatory diseases characterized by cytokine release syndrome.
Authors
- Tao Yang (ORCID: https://orcid.org/0000-0003-2002-7326)
- Shiyou Wang (ORCID: https://orcid.org/0000-0003-1901-3920)
- Shengchuan Chen
- Dapei Li (ORCID: https://orcid.org/0000-0003-2743-8435)
- Rongsheng Wu
- Sudan He (ORCID: https://orcid.org/0000-0002-0846-1210)
- Guodi Liu
- Cheng‐Feng Qin (ORCID: https://orcid.org/0000-0002-0632-2807)
- Haiping Yao (ORCID: https://orcid.org/0009-0005-5085-8819)
- Zhiqiang Chen (ORCID: https://orcid.org/0000-0002-2109-7767)
- Yuanqing He (ORCID: https://orcid.org/0000-0003-3731-3505)
- Siying Liu (ORCID: https://orcid.org/0009-0005-8616-7569)
- Jianfeng Dai (ORCID: https://orcid.org/0000-0002-9608-8064)
- Jingfei Zhu (ORCID: https://orcid.org/0000-0002-8378-0801)
- Yi Yuan (ORCID: https://orcid.org/0009-0006-6519-5314)
- Feng Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Soochow University (CN)
- Suzhou Institute of Systems Medicine (CN)
- Institute of Microbiology (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1097/hep.0000000000001101
- Citations
- 4
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 2.17