<i>Fusobacterium nucleatum</i> extracellular vesicles are enriched in colorectal cancer and facilitate bacterial adhesion

<i>Fusobacterium nucleatum</i> in colorectal cancer (CRC) tissue is implicated at multiple stages of the disease, while the mechanisms underlying bacterial translocation and colonization remain incompletely understood. Herein, we investigated whether extracellular vesicles derived from <i>F. nucleatum</i> (FnEVs) have impacts on bacterial colonization. In mice with colitis-related CRC, a notable enrichment of FnEVs was observed, leading to a significant increase in intratumor colonization by <i>F. nucleatum</i> and accelerated progression of CRC. The enrichment of FnEVs in clinical CRC tissues was demonstrated. Subsequently, we revealed that FnEVs undergo membrane fusion with CRC cells, leading to the transfer and retention of FomA on recipient cell surfaces. Given its ability to facilitate <i>F. nucleatum</i> autoaggregation through interaction with FN1441, the presence of FomA on CRC cell surfaces presents a target for bacterial adhesion. Collectively, the findings unveil a mechanism used by EVs to prepare a niche conducive for bacterial colonization in distal organs.

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Publication Details

Journal
Science Advances
Published
2024-09-20
DOI
https://doi.org/10.1126/sciadv.ado0016
Citations
29
Primary Topic
Bacterial Infections and Vaccines
Type
article
Field-Weighted Citation Impact
10.00
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article

Fusobacterium nucleatum extracellular vesicles are enriched in colorectal cancer and facilitate bacterial adhesion

Xian Peng, Wenming Yang, Chenchen Zhou, Jinhang Gao et al.
29 citations
Science Advances
Bacterial Infections and Vaccines
10.00
article

Fusobacterium nucleatum extracellular vesicles are enriched in colorectal cancer and facilitate bacterial adhesion

Xian Peng, Wenming Yang, Chenchen Zhou, Jinhang Gao, Quan Yuan, Bing Hu, Wanyi Luo, Xin Xu, Canhua Huang, Xuedong Zhou, Tao Gong, Lei Cheng, Na Xie, Yuqing Li, Rui Liu, Xin Zheng
article en
29 citations

Abstract

<i>Fusobacterium nucleatum</i> in colorectal cancer (CRC) tissue is implicated at multiple stages of the disease, while the mechanisms underlying bacterial translocation and colonization remain incompletely understood. Herein, we investigated whether extracellular vesicles derived from <i>F. nucleatum</i> (FnEVs) have impacts on bacterial colonization. In mice with colitis-related CRC, a notable enrichment of FnEVs was observed, leading to a significant increase in intratumor colonization by <i>F. nucleatum</i> and accelerated progression of CRC. The enrichment of FnEVs in clinical CRC tissues was demonstrated. Subsequently, we revealed that FnEVs undergo membrane fusion with CRC cells, leading to the transfer and retention of FomA on recipient cell surfaces. Given its ability to facilitate <i>F. nucleatum</i> autoaggregation through interaction with FN1441, the presence of FomA on CRC cell surfaces presents a target for bacterial adhesion. Collectively, the findings unveil a mechanism used by EVs to prepare a niche conducive for bacterial colonization in distal organs.

Science AdvancesVol. 10(38)
Sichuan University (CN), West China Medical Center of Sichuan University (CN), West China Hospital of Sichuan University (CN), National Clinical Research (US), Stomatology Hospital (CN)
Openalex Percentile: Top 1%
Bacterial Infections and Vaccines
10.00
DOIOpen Access PDFOpenAlex
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