Exploring biological activities of novel Schiff bases derived from amlodipine and <i>in silico</i> molecular modeling studies
<b>Aim:</b> Calcium channel antagonists are of considerable interest in treating elevated blood pressure and its pathologies.<b>Materials & methods:</b> Schiff base derivatives of amlodipine were produced to check its urease inhibition potentials as well antibacterial and antioxidant activities. Structural illustration along with chemical characterization were achieved by spectral techniques (<sup>1</sup>H NMR, FTIR, <sup>13</sup>C NMR) and docking studies also performed.<b>Results & conclusion:</b> 3g displayed remarkable anti-hypertensive activity compared with parent drug. 3b, 3f and 3g showed urease inhibition potentials. These compounds can aid as lead for further investigations since they exhibited comparable or superior interactions.
Authors
- M. A. Bhat (ORCID: https://orcid.org/0000-0001-8426-4692)
- Breena Awan (ORCID: https://orcid.org/0000-0003-1100-9062)
- Farhat Ullah (ORCID: https://orcid.org/0000-0001-7907-0842)
- Anum Masood (ORCID: https://orcid.org/0000-0002-9879-9038)
- Mohsin Abbas Khan (ORCID: https://orcid.org/0000-0002-3178-5467)
- Asim Raza (ORCID: https://orcid.org/0000-0001-6059-7804)
- Saharish Khaliq (ORCID: https://orcid.org/0000-0002-0908-9721)
- Javaid Ahmed
- Ramsha Hanif
Institutions
- University of the Punjab (PK)
- Islamia University of Bahawalpur (PK)
- King's College London (GB)
- King Saud University (SA)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1080/17568919.2024.2401313
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University