Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
This study establishes a single-cell atlas of hepatic stellate cells across various liver injuries, highlighting a conserved activation process between different injuries and across species. The discovery of novel activating ligands and the biomarker COLEC10 in human plasma could be used to enhance diagnostic and therapeutic strategies. Additionally, the conserved activation process supports the use of any mouse model for mechanistic studies and testing of new anti-fibrotic compounds, streamlining preclinical research efforts.
Authors
- Leo A. van Grunsven (ORCID: https://orcid.org/0000-0002-0990-7034)
- Vincent Merens (ORCID: https://orcid.org/0000-0002-8249-4838)
- Nouredin Messaoudi (ORCID: https://orcid.org/0000-0003-2799-2604)
- Hendrik Reynaert (ORCID: https://orcid.org/0000-0002-2701-5777)
- Stefaan Verhulst (ORCID: https://orcid.org/0000-0001-6566-6071)
- Elif Gürbüz (ORCID: https://orcid.org/0000-0001-5072-6887)
- Elisabeth Knetemann (ORCID: https://orcid.org/0000-0003-4975-1844)
- Vincent De Smet (ORCID: https://orcid.org/0000-0002-1294-3191)
Institutions
- Vrije Universiteit Brussel (BE)
- Universitair Ziekenhuis Brussel (BE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101223
- Citations
- 16
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.19
Funders
- Fonds Wetenschappelijk Onderzoek