The hemostatic activity and Mechanistic roles of glucosyloxybenzyl 2-isobutylmalate extract (BSCE) from Bletilla striata (Thunb.) Rchb.f. in Inhibiting pulmonary hemorrhage
BSCE exhibits significant hemostatic and protective effects on <i>Z</i>.<i>officinale</i>-induced pulmonary hemorrhage in rats by improving hematological parameters, reducing lung tissue damage, and modulating the coagulation and fibrinolytic systems. The study provides evidence supporting the potential of BSCE as a therapeutic agent for hemorrhagic diseases, with its efficacy linked to multi-target and multi-pathway interactions.
Authors
- Kailang Mu (ORCID: https://orcid.org/0009-0007-0039-2373)
- Qingwen Sun (ORCID: https://orcid.org/0000-0003-0848-5017)
- Leqiang Peng
- Fei Ran
- Xin-Yue Zhang (ORCID: https://orcid.org/0009-0008-5272-0890)
- Yuchen Liu (ORCID: https://orcid.org/0000-0003-0125-5067)
- Gang Liu (ORCID: https://orcid.org/0000-0001-9270-6796)
- Yongping Zhang (ORCID: https://orcid.org/0000-0003-2267-6434)
- Jinmei Liu (ORCID: https://orcid.org/0000-0002-1731-9769)
- Feng Guo (ORCID: https://orcid.org/0000-0001-9627-7722)
- Lingli Zhou (ORCID: https://orcid.org/0000-0003-1467-2812)
- Fu-Dao Wei
- Ling-li Zhu
Institutions
- Guizhou University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38203
- Citations
- 3
- Primary Topic
- Biological and pharmacological studies of plants
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- National Natural Science Foundation of China