In Vitro Culture of Human Dermal Fibroblasts on Novel Electrospun Polylactic Acid Fiber Scaffolds Loaded with Encapsulated Polyepicatechin Physical Gels
Polyepicatechin (PEC) in a hydrogel has previously shown promise in enhancing physiological properties and scaffold preparation. However, it remains unclear whether PEC-based fibers can be applied in skin tissue engineering (STE). This study aimed to synthesize and characterize electrospun PEC physical gels and polylactic acid (PLA) scaffolds (PLA<sub>loaded</sub>PEC<sub>sub</sub>) for potential use as constructs with human dermal fibroblasts (HDFs). PEC was produced through enzymatic polymerization, as confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) demonstrated the feasibility of producing PLA<sub>loaded</sub>PEC<sub>sub</sub> by electrospinning. The metabolic activity and viability of HDFs cocultured with the scaffolds indicate that PLA<sub>loaded</sub>PEC<sub>sub</sub> is promising for the use of STE.
Authors
- Alfredo Maciel-Cerda (ORCID: https://orcid.org/0000-0002-3990-3720)
- Gertrudis Hortensia González-Gómez (ORCID: https://orcid.org/0000-0002-8187-8573)
- Eliza Miranda-Buendía (ORCID: https://orcid.org/0000-0001-8303-6292)
- Maykel González‐Torres (ORCID: https://orcid.org/0000-0003-3899-4410)
Institutions
- Instituto Nacional de Rehabilitación (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Gels
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3390/gels10090601
- Citations
- 1
- Primary Topic
- Electrospun Nanofibers in Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.17
Funders
- Universidad Nacional Autónoma de México