Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>KPC-3</sub> from foreign fighters evacuated from Ukraine
Genomic surveillance detected clonal <i>Escherichia coli</i> sequence type-361 isolates carrying <i>bla</i><sub>NDM-5</sub>, <i>bla</i><sub>KPC-3</sub>, <i>bla</i><sub>CTX-M-15</sub>, and <i>rmtB1</i> from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the <i>bla</i><sub>CMY-145</sub> AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.
Authors
- Jason R. Smedberg
- Melissa J. Martin (ORCID: https://orcid.org/0000-0002-8772-9392)
- Cole Anderson (ORCID: https://orcid.org/0000-0002-4366-6166)
- Ana Ong
- Yoon I. Kwak (ORCID: https://orcid.org/0000-0002-1198-5437)
- Iryna Kovalenko (ORCID: https://orcid.org/0000-0001-5075-4634)
- Patrick McGann (ORCID: https://orcid.org/0000-0003-1548-9438)
- Ting L. Luo (ORCID: https://orcid.org/0000-0002-6103-1981)
- Jason W. Bennett (ORCID: https://orcid.org/0000-0001-5879-2037)
- Viacheslav Kondratiuk (ORCID: https://orcid.org/0000-0002-2316-7941)
- Joshua S. Hawley-Molloy (ORCID: https://orcid.org/0000-0003-0473-6739)
- François Lebreton (ORCID: https://orcid.org/0000-0002-7157-5026)
- Joanna M. Kettlewell (ORCID: https://orcid.org/0000-0002-6718-6220)
- Henry D. Dao
- Valentyn Kovalchuk
- Brandon J. Plaza
Institutions
- Landstuhl Regional Medical Center (DE)
- National Pirogov Memorial Medical University, Vinnytsya (UA)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1128/aac.01090-24
- Citations
- 12
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.04