Exploring Innovative Liquid-Phase Peptide Synthesis Strategies with Silane-Containing Molecules

We developed a novel convergent LPPS platform, SYNCSOL, employing silane-containing molecules.SYNCSOL incorporates N-to-C coupling, a new protecting group, and a detachable solubilizing tag.This platform efficiently produces high-quality peptide fragments, enabling fragment condensation and C-terminal modifications.SYNCSOL enhances LPPS flexibility and promises to improve peptide manufacturing productivity.Convergent liquid-phase peptide synthesis (LPPS) is a powerful method for producing short and medium-sized peptides.However, traditional LPPS is limited by side reactions, necessitating an extended period for process development.To address this challenge, we have developed a novel coupling method, new protecting groups, and novel solubilizing tags for LPPS, utilizing silane-containing molecules.