Consuming Cottonseed Oil For One Month Improves Total Cholesterol And Low-density Lipoproteins In Healthy Adults

Hyperlipidemia (HLD) is a risk factor for cardiovascular disease. Consuming cottonseed oil (CSO) has been shown to improve total cholesterol (TC) and low-density lipoprotein (LDL) levels. The daily recommendation for dietary oil consumption is 30 g. To our knowledge, it is unknown if this amount of CSO can improve lipid levels and how different doses of CSO impact lipid levels. PURPOSE: To explore how high-density lipoprotein (HDL), triglyceride (TG), TC, and LDL levels are affected by consuming 30 or 60 g of CSO compared to olive oil (OO) after 28 days. METHODS: Participants (n = 48, ages: 18-55 years, BMI: 18-27 kg/m2) were randomly assigned to consume smoothies containing CSO or OO each day for 28 days. Serum lipid values were measured with a lipid panel from a fasting blood draw pre- and post- intervention. Statistical analysis was conducted using delta change between pre- and post- intervention with a paired t-test in Excel (16.66.1). SUMMARY OF RESULTS: Total cholesterol levels significantly decreased when consuming 60 g of CSO compared to OO (Δ = -11.33 ± 13.36 mg/dL vs +4.55 ± 13.83 mg/dL, CSO vs OO, p = .01). LDL levels also significantly decreased when consuming 60 g of CSO compared to OO (Δ = -14.58 ± 9.42 mg/dL vs -0.25 ± 8.94 mg/dL, CSO vs OO, p = < .01). There were no other differences between groups (p = > .05). CONCLUSION: Consuming CSO may be useful in preventing HLD at a higher dose than what is recommended. Cotton Incorporated: 22-070