Chronic sleep deprivation induces erectile dysfunction through increased oxidative stress, apoptosis, endothelial dysfunction, and corporal fibrosis in a rat model
CSD severely impairs erectile function in rats. When exposed to CSD, rats exhibit significantly elevated oxidative stress levels, which lead to increased tissue apoptosis, endothelial dysfunction, and ultimately irreversible fibrotic changes in the tissues. Further researches into the potential molecular mechanisms are needed to identify possible therapeutic targets for ED related to CSD.
Authors
- Yuyang Zhang (ORCID: https://orcid.org/0009-0003-2906-4892)
- Xingliang Feng (ORCID: https://orcid.org/0000-0002-0003-0301)
- Xu Wu (ORCID: https://orcid.org/0000-0003-2130-1980)
- Mingqin Su
- Hui Jiang (ORCID: https://orcid.org/0000-0002-6256-2733)
- Guodong Liu (ORCID: https://orcid.org/0000-0003-3190-9148)
- Dongdong Tang (ORCID: https://orcid.org/0000-0002-9966-3642)
- Xiansheng Zhang
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Soochow University (CN)
- The First People's Hospital of Changzhou (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- The Journal of Sexual Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1093/jsxmed/qdae118
- Citations
- 11
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- National Natural Science Foundation of China