Quercetin relieves compression-induced cell death and lumbar disc degeneration by stabilizing HIF1A protein
Our study identified HIF1A as a protective factor against compression-induced cell death in NPMSCs. Quercetin, a bioactive compound found in the traditional Chinese medicine formula SGD, improved the survival of NPMSCs and alleviated LDD progression by stabilizing HIF1A. Targeting the HIF1A pathway through natural compounds like quercetin could represent a promising strategy for the clinical management of LDD and potentially other degenerative disc diseases.
Authors
- Junxiao Ren (ORCID: https://orcid.org/0000-0003-4203-1289)
- Yongqing Xu (ORCID: https://orcid.org/0000-0003-1588-4489)
- Rui Xin (ORCID: https://orcid.org/0000-0002-6479-1070)
- Chuan Li (ORCID: https://orcid.org/0000-0002-2773-5037)
- Xiaoping Cui (ORCID: https://orcid.org/0000-0003-4374-6227)
Institutions
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37349
- Citations
- 4
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.70