The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity
Our results suggest that the AT NPY/melanocortin system, particularly the MC3R, may be involved in the neuroendocrine regulation of adipocyte metabolism. Altogether, our work shows MC3R is under the control of the ghrelin/leptin duo, is reduced in patients with obesity and prediabetes, and may constitute a therapeutic target in obesity.
Authors
- Daniela Silva (ORCID: https://orcid.org/0000-0002-4276-5920)
- Ana Margarida Abrantes (ORCID: https://orcid.org/0000-0003-4185-7871)
- Tamaeh Monteiro‐Alfredo (ORCID: https://orcid.org/0000-0001-5514-0797)
- Paulo Matafome
- Flávio Reis (ORCID: https://orcid.org/0000-0003-3401-9554)
- Sofia Viana
- Hans Eickhoff (ORCID: https://orcid.org/0000-0003-1416-456X)
- Ana Salomé Pires (ORCID: https://orcid.org/0000-0001-7994-4650)
- Inês Falcão‐Pires (ORCID: https://orcid.org/0000-0003-1937-3782)
- Maria Filomena Botelho (ORCID: https://orcid.org/0000-0001-7202-1650)
- Eduardo Lopes (ORCID: https://orcid.org/0000-0003-0968-2530)
- Raquel Maria Fino Seiça (ORCID: https://orcid.org/0000-0002-8378-0895)
Institutions
- Universidade do Porto (PT)
- Polytechnic Institute of Coimbra (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Molecular and Cellular Endocrinology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1016/j.mce.2024.112367
- Citations
- 3
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.82
Funders
- Fundação para a Ciência e a Tecnologia