FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors
Our study reveals the critical role of FTO in the aggressive growth hormone-secreting pituitary neuroendocrine tumors subtype and suggests FTO may represent a new therapeutic target for refractory/persistent SGGH.
Authors
- Xiaoqiong Bao (ORCID: https://orcid.org/0009-0000-0631-3524)
- Hongzhe Zhao (ORCID: https://orcid.org/0009-0005-9859-0452)
- Aiqun Liu (ORCID: https://orcid.org/0000-0002-1077-5585)
- Lingxing Zeng (ORCID: https://orcid.org/0000-0002-0846-8762)
- Chunling Xue (ORCID: https://orcid.org/0009-0007-9616-004X)
- Yuanzhong Yang (ORCID: https://orcid.org/0000-0002-1458-3054)
- Ziming Chen (ORCID: https://orcid.org/0000-0001-5987-0148)
- Wanming Hu
- Zeming Yan
- Depei Li (ORCID: https://orcid.org/0000-0002-4317-1606)
- Ruihong Bai (ORCID: https://orcid.org/0009-0001-0050-9152)
- Boyuan Yao (ORCID: https://orcid.org/0000-0001-6448-2588)
- Jixiang Zhao
- Zhixiang Zuo (ORCID: https://orcid.org/0000-0002-2492-2689)
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0002-8480-9004)
- Zhe Zhu (ORCID: https://orcid.org/0000-0002-2205-9068)
- Qilin Zhang (ORCID: https://orcid.org/0000-0002-0122-3201)
- Yunzhi Zou (ORCID: https://orcid.org/0000-0003-2507-5546)
- Zekun Deng (ORCID: https://orcid.org/0009-0002-9958-3228)
- Zhen Ye (ORCID: https://orcid.org/0009-0000-8766-8262)
- Guanghao Yue
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0002-1121-0770)
- Jintong Cheng
- Rong Xiang
- Jialiang Zhang (ORCID: https://orcid.org/0000-0001-6978-2168)
Institutions
- NewYork–Presbyterian Hospital (US)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Columbia University Irving Medical Center (US)
- Sun Yat-sen University Cancer Center (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12943-024-02117-5
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province