FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Our study reveals the critical role of FTO in the aggressive growth hormone-secreting pituitary neuroendocrine tumors subtype and suggests FTO may represent a new therapeutic target for refractory/persistent SGGH.

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Publication Details

Journal
Molecular Cancer
Published
2024-09-20
DOI
https://doi.org/10.1186/s12943-024-02117-5
Citations
7
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
1.64

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article

FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Xiaoqiong Bao, Hongzhe Zhao, Aiqun Liu, Lingxing Zeng et al.
7 citations
Molecular Cancer
RNA modifications and cancer
1.64
article

FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors

Xiaoqiong Bao, Hongzhe Zhao, Aiqun Liu, Lingxing Zeng, Chunling Xue, Yuanzhong Yang, Ziming Chen, Wanming Hu, Zeming Yan, Depei Li, Ruihong Bai, Boyuan Yao, Jixiang Zhao, Zhixiang Zuo, Zhenhua Zhang, Zhe Zhu, Qilin Zhang, Yunzhi Zou, Zekun Deng, Zhen Ye, Guanghao Yue, Xiaobing Jiang, Jintong Cheng, Rong Xiang, Jialiang Zhang
article en
7 citations

Abstract

Our study reveals the critical role of FTO in the aggressive growth hormone-secreting pituitary neuroendocrine tumors subtype and suggests FTO may represent a new therapeutic target for refractory/persistent SGGH.

Molecular CancerVol. 23(1)
NewYork–Presbyterian Hospital (US), Sun Yat-sen University (CN), Fudan University (CN), Columbia University Irving Medical Center (US), Sun Yat-sen University Cancer Center (CN), Huashan Hospital (CN)
National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province
Zero hunger
Openalex Percentile: Top 16%
RNA modifications and cancer
1.64
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