An exploratory graphical analysis of the Montgomery-Åsberg Depression Rating Scale pre- and post-treatment using pooled antidepressant trial secondary data
An 8-item one-community variant of the MADRS may provide optimal performance when conducting network analyses of antidepressant clinical trial outcomes. Findings suggest that interventions targeting low mood and lassitude might be most efficacious in treating depression among clinical trial participants. Further considerations of the potential impact on trial design and analysis should be explored.
Authors
- David Hevey (ORCID: https://orcid.org/0000-0003-2844-0449)
- Susan Brannick
- David F. Byrne (ORCID: https://orcid.org/0000-0002-0587-4677)
- Pim J. Cuijpers (ORCID: https://orcid.org/0000-0001-5497-2743)
- Robert M. Carney (ORCID: https://orcid.org/0000-0002-0737-6655)
- Emma K. Wallace (ORCID: https://orcid.org/0000-0002-9315-2956)
- Kenneth E. Freedland (ORCID: https://orcid.org/0000-0002-3118-9913)
- Suzanne Guérin (ORCID: https://orcid.org/0000-0002-6744-7590)
- Bishember Kathuria
- Vincent McDarby
- Frank Doyle (ORCID: https://orcid.org/0000-0002-3785-7433)
- Fiona Boland (ORCID: https://orcid.org/0000-0003-3228-0046)
- Alexandra Lelia Dima (ORCID: https://orcid.org/0000-0002-3106-2242)
- Arunangshu Ghoshal (ORCID: https://orcid.org/0000-0001-9975-2568)
Institutions
- University College Dublin (IE)
- University Health Network (CA)
- Washington University in St. Louis (US)
- Trinity College Dublin (IE)
- University College Cork (IE)
- Royal Dublin Society (IE)
- Princess Margaret Cancer Centre (CA)
- Sant Joan de Déu Research Foundation (ES)
- Novartis (Ireland) (IE)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1016/j.jad.2024.09.087
- Citations
- 2
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 1.02
Funders
- Irish Research Council