Epinephrine infusion as an adjuvant treatment for breakthrough reactions during desensitization to methotrexate
Desensitization protocols can induce temporary tolerance to a drug which has previously caused an allergic response, and thus facilitate appropriate and timely medical management.1 Rapid desensitization protocols have proven safe and cost-effective; in the context of cancer treatment, desensitization can allow patients to remain on first-line therapy, which can improve morbidity and survival.2 Breakthrough allergic reactions are frequent during desensitization, but tend to remit during subsequent procedures.
Authors
- David Alejandro Mendoza-Hernández (ORCID: https://orcid.org/0000-0002-6162-7136)
- Paul Turner (ORCID: https://orcid.org/0000-0001-9862-5161)
- Carla Toledo-Salinas
Institutions
- Tecnológico Nacional de México (MX)
- Centro Médico ABC (MX)
- Vietnam National Children's Hospital (VN)
- Imperial College London (GB)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.waojou.2024.100965
- Citations
- 1
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Imperial College London
- Imperial College Healthcare NHS Trust
- Manchester Biomedical Research Centre
- Medical Research Council
- NIHR Imperial Biomedical Research Centre