Exploring the causal effects of serum lipids and lipidomes on lewy body dementia: a Mendelian randomization study
Elevated LDL-C and RC levels are significant risk factors for LBD, with RC also impacting APOE4-carrying LBD. Glycerophospholipids play a crucial role in the pathogenesis of LBD, but the specific components that play a role differ from those with the APOE4 carries. These findings highlight the importance of lipid metabolism in LBD and APOE4 subtypes.
Authors
- Qingyun Yu
- Guanrui Pan (ORCID: https://orcid.org/0000-0002-2527-7984)
- Xiaowei Ma (ORCID: https://orcid.org/0000-0002-3062-4063)
- Tianzhou Shen
- Long Jiang (ORCID: https://orcid.org/0000-0002-1506-7385)
- Qingan Fu
- Zhekang Liu
Institutions
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3389/fendo.2024.1456005
- Citations
- 7
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.58
Funders
- National Natural Science Foundation of China