Transcriptomics-based anti-tuberculous mechanism of traditional Chinese polyherbal preparation NiuBeiXiaoHe intermediates
MTB infection led to extensive changes in host gene expression and mainly caused the host's anti-TB immune responses. The treatment using high-dose NBXH partially repaired the abnormal gene expression, further enhanced the anti-TB immunity included autophagy and NK cell-mediated cytotoxicity, and had a certain inhibitory effect on overactivated immune responses.
Authors
- Xueqiong Wu (ORCID: https://orcid.org/0000-0001-8894-1929)
- Xiaojun Li (ORCID: https://orcid.org/0000-0002-7526-0558)
- Qianqian Ma (ORCID: https://orcid.org/0000-0001-8579-8020)
- Yan Liang (ORCID: https://orcid.org/0000-0002-7103-6428)
- Junxian Zhang (ORCID: https://orcid.org/0000-0003-4725-1854)
- Jie Wang (ORCID: https://orcid.org/0000-0002-3879-0971)
- Nan Wang (ORCID: https://orcid.org/0009-0003-9735-4314)
Institutions
- Hebei North University (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3389/fphar.2024.1415951
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78