Frequency of KRAS and BRAF mutations in colorectal carcinoma and their association with clinical-pathological characteristics in a tertiary hospital in Kenya
Colorectal carcinoma in our patients is more common in males and tend to occur at a younger age. The patients tend to have a high tumor pathological stage and nodal involvement at diagnosis. The high frequency of <i>KRAS</i> exon 2,3,4 mutation and low frequency <i>of BRAF V600E</i> mutations is similar to what has been reported in literature.
Authors
- Allan Njau (ORCID: https://orcid.org/0000-0002-3566-0629)
- Ancent Nzioka (ORCID: https://orcid.org/0000-0002-8822-1937)
- James O. Ogutu (ORCID: https://orcid.org/0000-0002-9076-624X)
- Samuel Gakinya (ORCID: https://orcid.org/0000-0003-0876-7313)
- Abdulkarim Abdallah
Institutions
- Kenyatta University (KE)
- Kenyatta National Hospital (KE)
- Aga Khan University Nairobi (KE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.3389/fmed.2024.1433120
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.28