Ulinastatin attenuated cardiac ischaemia/reperfusion injury by suppressing activation of the tissue kallikrein‐kinin system
Treatment with ulinastatin exerts a protective influence on cardiac reperfusion by suppressing activation of the kallikrein-kinin system. Our findings highlight the potential of targeting kallikrein /bradykinin receptors to alleviate endothelial dysfunction, thus improving cardiac IRI.
Authors
- Qin Zhang (ORCID: https://orcid.org/0000-0002-5664-5823)
- Ailin Luo (ORCID: https://orcid.org/0000-0001-8826-5588)
- Xiaochuan Wang (ORCID: https://orcid.org/0000-0001-8207-0042)
- Hang Ruan (ORCID: https://orcid.org/0000-0001-7738-0177)
- Xiao Ran (ORCID: https://orcid.org/0000-0001-5025-2538)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-18
- DOI
- https://doi.org/10.1111/bph.16477
- Citations
- 7
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 3.07
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Tongji Medical College, Huazhong University of Science and Technology