Effect of konjac glucomannan on gut microbiota from hyperuricemia subjects in vitro: fermentation characteristics and inhibitory xanthine oxidase activity

In conclusion, the effect of KGM on hyperuricemia subjects was investigated based on the gut microbiota <i>in vitro</i>. In the present study. It was found that KGM could be metabolized into SCFAs by HUA gut microbiota. Furthermore, KGM could modulate the structure of HUA gut microbiota. At the genus level, KGM could decrease the relative abundances of <i>Butyricicoccus</i>, <i>Eisenbergiella</i>, and <i>Enterococcus</i>, while <i>Lachnoclostridium</i> and <i>Lachnospiraceae</i> in HUA gut microbiota were significantly increased by the addition of KGM. The metabolites of gut microbiota, such as SCFAs, might be responsible for the inhibition of XOD activity. Thus, KGM exhibited a superior probiotic function on the HUA gut microbiota, which is expected as a promising candidate for remodeling the HUA gut microbiota.